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Our bracket blitz series continues with a comprehensive breakdown of the Midwest region, featuring potential upsets and championship predictions from our expert panel.

• Houston enters as the top seed, expected to dominate SIU Edwardsville by potentially 50 points
• Gonzaga appears significantly under-seeded as a 5-seed, ranking among top 10 in KenPom metrics
• McNeese State vs Clemson sparks debate as the classic 5-12 upset potential with heavy betting action on McNeese
• Illinois-Xavier matchup presents interesting stylistic contrast with Xavier's three-point shooting excellence
• Florida emerges as surprising championship favorite after dominating SEC tournament
• Multiple 13-seeds identified with upset potential, particularly Akron, Yale and Lipscomb
• Panel predicts this region will be the "bracket of chaos" with multiple upsets
• Strategy tips shared for picking upsets and constructing winning brackets

Remember to bet responsibly, don't chase losses, and enjoy the madness of March basketball!