Are chambers of commerce part of a national or state governing structure? This is a question I hear regularly. The simple answer is …. NO. The Cape Girardeau Area Chamber of Commerce is a stand-alone, not-for-profit membership corporation with a more than 100 year history. We exist for, and because of our membership. Unlike many other non-profit groups, we are not a subset of a national group. But wait a minute. Isn’t there a U.S. Chamber of Commerce and a Missouri Chamber of Commerce and