Semiconductor spin qubits promise scalable quantum computing, blending long-lived spin physics with semiconductor fabrication. Over the past two decades, Lieven Vandersypen has been at the forefront of this journey—pushing qubit control, larger processors, and architecture-aware experiments, while helping Delft become a model quantum ecosystem. This conversation offers a rare chance to hear from a scientist shaping both the field and the path from research to real-world quantum technology.