Persistent depressive disorder, known as dysthymia or low-grade depression, is less severe than major depression but more chronic. It occurs twice as often in women as in men. Persistent depressive disorder (PDD) is a serious and disabling disorder that shares many symptoms with other forms of clinical depression. It is generally experienced as a less severe but more chronic form of major depression. PDD was referred to as dysthymia in previous versions of the DSM. PDD is characterized by depressed mood experienced most of the time for at least two years. In children and adolescents, mood can be irritable rather than depressed. In addition to depression or irritable mood, at least two of the following must be present: insomnia or excessive sleep, low energy or fatigue, low self-esteem, poor appetite or overeating, poor concentration or indecisiveness, and feelings of hopelessness. More severe symptoms marking major depression are often absent in PDD—this includes anhedonia (the inability to feel pleasure), psychomotor symptoms (particularly lethargy or agitation), and thoughts of death or suicide. Tune in and learn all about Persistent Depressive Disorder!