Multiple myeloma is one of the most fascinating hematological malignancies and I couldn't think of a better way to kick start the "Liquid tumor series". Today, we have with us Dr Jacob Laubach, author of the section on "Multiple myeloma-clinical features and diagnosis" on UpToDate, one of the most referenced and trusted information sources for all internists. Join us in our conversation about the pathophysiology, typical and atypical presentations and the core principles of diagnosis of multiple myeloma.