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Lisa Swanson, MD, a board-certified dermatologist and pediatric dermatologist with Ada West Dermatology in Boise, Idaho, reviews the role that Janus kinases (JAKs) play in the inflammatory process and the benefits of inhibiting this enzyme when treating patients with atopic dermatitis. She also elaborates upon her experiences using the newly approved JAK inhibitors in her own patients. Dr. Swanson then outlines things to consider before starting patients on JAK inhibitors.