Recorded live at Brain Innovation Days 2025, this episode explores how environmental exposures shape brain health across our lifespan. Host Sam Pauly speaks with Geert Dom (European Psychiatric Association), Bart Depreitere (University Hospitals Leuven), and Silke Matura (Goethe University Hospital) about the profound impact of childhood adversity, nutrition, urban living, and lifestyle choices on brain development and disease risk. From ultra-processed foods accelerating cognitive decline to how thoughtful city design can protect mental health, this conversation reveals why we need systemic change in our environments to safeguard brain health for current and future generations.