Pastor Mike anchors the sermon in Romans 12:1-2, emphasizing the importance of presenting our bodies to God as a form of worship. Key points include the creation and fall of man, the incarnation of Jesus, and the role of our bodies in God's redemptive story. Practical applications are provided, focusing on physical worship, stewardship, and loving actions through bodily presence. The sermon also touches on themes like aging, suffering, work, and desires, encouraging believers to steward their bodies for God's glory while maintaining an eternal perspective.