Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell

Types and Protect Against Senescence

Lu, J., Rao, S. R., Knowles, H. ... · cell biology · Botnar Research

Centre, Nuffield Department of Orthopaedics, Rheumatology and

Musculoskeletal Sciences, University of Oxford, Oxford, UK · biorxiv

Longevity Relevance Analysis (5)

Bisphosphonates may trigger anti-aging effects by protecting against

cellular senescence and modifying the plasma proteome. The paper

addresses mechanisms that could potentially influence the root causes

of aging, rather than merely treating age-related diseases.

Wednesday, March 26, 2025

[11]Targeted intervention of senescence induced by a 5' half fragment

of tRNASec(NCA) with antisense oligonucleotide extends healthspan and

lifespan in mice

Cao, K.-Y., Bai, L.-B., Zhang, D. ... · genetics · State Key Laboratory

of Quality Research in Chinese Medicine, Macau University of Science

and Technology · biorxiv

Longevity Relevance Analysis (5)

The paper claims that targeting the 5'-tRNASec(NCA) half with antisense

oligonucleotides can ameliorate aging markers and extend healthspan and

lifespan in mice. This research addresses a potential root cause of

aging by identifying tRNA damage as a novel aging hallmark and

proposing a therapeutic intervention, which is significant for the

field of longevity research.

Tuesday, March 25, 2025

[17]Epigenetic editing at individual age-associated CpGs affects the

genome-wide epigenetic aging landscape.

Sven Liesenfelder, Mohamed H Elsafi Mabrouk, Jessica Iliescu ... ·

Nature aging · Institute for Stem Cell Biology, RWTH Aachen University

Medical School, Aachen, Germany. · pubmed

Longevity Relevance Analysis (5)

The paper claims that epigenetic editing at age-associated CpG sites

can modulate the epigenetic aging network and interfere with epigenetic

clocks. This research is relevant as it explores the mechanisms of

aging at the epigenetic level, potentially addressing the root causes

of aging rather than merely treating age-related diseases.

Saturday, March 22, 2025

[45]Exosomes Released from Senescent Cells and Circulatory Exosomes

Isolated from Human Plasma Reveal Aging-associated Proteomic and Lipid

Signatures

Patel, S. K., Bons, J., Rose, J. P. ... · cell biology · Buck Institute

for Research on Aging · biorxiv

Longevity Relevance Analysis (5)

The paper identifies specific proteomic and lipidomic signatures in

exosomes from senescent cells and human plasma that are associated with

aging. This research is relevant as it explores the mechanisms of

cellular senescence, which is a fundamental process in aging and

age-related diseases, potentially leading to therapeutic targets for

longevity interventions.

Wednesday, March 26, 2025

[15]SIRT6 activator fucoidan extends healthspan and lifespan in aged

wild-type mice

Biashad, S. A., Hillpot, E., Morandini, F. ... · molecular biology ·

University of Rochester · biorxiv

Longevity Relevance Analysis (4)

Fucoidan supplementation activates SIRT6, leading to increased lifespan

and reduced frailty in aged mice. The paper is relevant as it

investigates a potential pharmacological approach to enhance longevity

through the activation of a protein associated with lifespan extension

and healthspan improvement.

The podcast is auto-generated by NotebookLM and frankly, has occasional mistakes on the date of the paper and the authors, but mostly describes the overall idea of the research and papers well. I'm trying it out for a few weeks to see if it's worth continuing to generate the podcast.