In this episode of Longevity Papers, we analyze groundbreaking research for biotech longevity scientists: JULY 2025 BREAKTHROUGHS:

1. Beyond the Pseudogene: p17/PERMIT as Mitochondrial Trafficking Protein (Albayram et al., Medical University of South Carolina, July 17)

• Reclassification of "junk DNA" reveals mitochondrial chaperone critical for mitophagy\n • Loss accelerates sarcopenia and neurodegeneration

• URL: https://pubmed.ncbi.nlm.nih.gov/40671432/

2. RICTOR Regulates Longevity via Methionine-Mitophagy Axis (Motwani et al., National Institute of Immunology, July 10)

• Vitamin B12-driven succinate accumulation activates mitophagy

• Extends C. elegans lifespan through conserved nutrient-sensing pathway

• URL: https://www.biorxiv.org/content/10.1101/2025.07.11.664440v1

3. Semaglutide Slows Epigenetic Aging in Humans (Corley et al., Weill Cornell, July 11)

• GLP-1 agonist reduced GrimAge by 1.4-4.9 years in clinical trial

• First evidence of epigenetic age reversal in HIV population\n • URL: https://www.medrxiv.org/content/10.1101/2025.07.09.25331038v1

4. ATF3 Deficiency in Vascular Aging (Nie et al., Huazhong University, July 11)

• Terazosin stabilizes ATF3-ATG7 autophagy loop

• Delays vascular smooth muscle cell senescence in aged mice

• URL: https://pubmed.ncbi.nlm.nih.gov/40641410/

5. Multi-Organ MRI Clocks Predict Mortality (MULTI Consortium, Columbia, July 12)

• Brain/immune aging signatures emerge as top mortality predictors

• 7-organ MRI analysis prioritizes 9 druggable targets

• URL: https://www.medrxiv.org/content/10.1101/2025.07.10.25331263v1

6. Primate Rejuvenation via Engineered Stem Cells (Siddique et al., KAUST, June 27)

• FOXO3-enhanced stem cells reversed multi-organ aging in monkeys

• Reduced epigenetic age across brain/immune/reproductive systems

• URL: https://pubmed.ncbi.nlm.nih.gov/40571786/

7. Biomarker-Driven Geroprotector Discovery (Shindyapina et al., Harvard, June 30)

• Platform identified selumetinib + vorinostat as lifespan-extenders

• MEK/HDAC inhibitors extended healthspan in male mice

• URL: https://www.biorxiv.org/content/10.1101/2025.06.26.661776v1

8. Engineered Telomerase RNA Therapy (Nagpal + Agarwal, Boston Children's, June 28)

• Synthetic TERC extended telomeres in patient-derived stem cells

• Solved delivery challenges for telomerase therapy

• URL: https://pubmed.ncbi.nlm.nih.gov/40579489/

9. ADIOL: Dietary Restriction's Neuroprotective Metabolite (Guijarro-Hernandez et al., UCSF, June 29)

• Key mediator of calorie restriction benefits

• Rescues APOE4-induced cellular stress

• URL: https://www.biorxiv.org/content/10.1101/2025.06.25.661551v1

10. Mitochondrial Stress Response Modulator FIP1L1 (Li et al., EPFL, June 26)

• Genetic mapping reveals conserved UPRmt regulator

• Links mitochondrial proteostasis to longevity pathways

• URL: https://www.biorxiv.org/content/10.1101/2025.06.26.661693v1

For full papers and daily longevity updates: https://longevitypapers.com

Keywords: longevity research, aging biomarkers, epigenetic clocks, mitophagy, stem cell therapy, telomeres, geroprotectors, dietary restriction, mitochondrial health, neurodegeneration