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Longevity Papers 2025-09-12
This week on Longevity Papers, we didn't find so many interesting papers so we go back to a classic research by Cynthia Kenyon, but also analyze recent research from longevitypapers.com
1) The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. (Kenyon, Cynthia 12 January 2011 , Phil. Trans. R. Soc. B3669–16 https://doi.org/10.1098/rstb.2010.0276 )
2) The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation (Koyuncu et al., University Hospital Cologne, Sept 4, 2025, https://pubmed.ncbi.nlm.nih.gov/40903652/ ) - Identifies EPS8 as a convergent aging factor promoting protein aggregation across multiple neurodegenerative diseases, with USP4 as a potential therapeutic target.
3) Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging (Zhang et al., University of Illinois Chicago, Sept 8, 2025, https://pubmed.ncbi.nlm.nih.gov/40920871/ ) - Demonstrates actual rejuvenation of aged hematopoietic stem cells through PF4 signaling, though systemic safety and lifespan effects remain to be proven.
We discuss why most papers this week represent incremental progress rather than paradigm shifts, the challenges of translating promising mouse studies to humans, and what experiments are needed to validate these findings for meaningful life extension. This podcast is AI generated and may contain errors.
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By Longevity PapersThis week on Longevity Papers, we didn't find so many interesting papers so we go back to a classic research by Cynthia Kenyon, but also analyze recent research from longevitypapers.com
1) The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. (Kenyon, Cynthia 12 January 2011 , Phil. Trans. R. Soc. B3669–16 https://doi.org/10.1098/rstb.2010.0276 )
2) The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation (Koyuncu et al., University Hospital Cologne, Sept 4, 2025, https://pubmed.ncbi.nlm.nih.gov/40903652/ ) - Identifies EPS8 as a convergent aging factor promoting protein aggregation across multiple neurodegenerative diseases, with USP4 as a potential therapeutic target.
3) Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging (Zhang et al., University of Illinois Chicago, Sept 8, 2025, https://pubmed.ncbi.nlm.nih.gov/40920871/ ) - Demonstrates actual rejuvenation of aged hematopoietic stem cells through PF4 signaling, though systemic safety and lifespan effects remain to be proven.
We discuss why most papers this week represent incremental progress rather than paradigm shifts, the challenges of translating promising mouse studies to humans, and what experiments are needed to validate these findings for meaningful life extension. This podcast is AI generated and may contain errors.