A CRISPR-Cas13-based strategy for targeting mRNA, utilizing guide RNA (gRNA) to replace segments with lethal sequences such as premature stop codons or toxic peptides is the malaria cure. Beginning with the Cas13-gRNA complex it targets mRNA, followed by mRNA cleavage and the integration of a repair template that modifies the sequence to signify the lethal replacement. CRISPR-Cas13 mechanism includes a gRNA binding, cleavage, and template-mediated replacement, along with the resulting translation of toxic or truncated proteins. Proteins such as PfPuf2 and DOZI trigger immune responses including splenic clearance and T-cell activation.