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Macrophage-derived thromboxane A2 drives neonatal cardiac regeneration
Lantz et al. reveal that neonatal heart regeneration relies on macrophages using the MERTK receptor to engulf dying cells, stimulating thromboxane A2 (TXA2) production. TXA2 activates the TP receptor on cardiomyocytes to induce proliferation via YAP signaling, an immune-metabolic pathway necessary for regeneration that is absent in adults.
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By KCYLantz et al. reveal that neonatal heart regeneration relies on macrophages using the MERTK receptor to engulf dying cells, stimulating thromboxane A2 (TXA2) production. TXA2 activates the TP receptor on cardiomyocytes to induce proliferation via YAP signaling, an immune-metabolic pathway necessary for regeneration that is absent in adults.
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