Psychologist Kimberley Wilson and Dr Xand van Tulleken take a journey around the human body, to find out what it can tell us about our innate capacity for change. In this episode, Kimberley and Xand focus on the heart, which has been branded the seat of emotion by generations of poets and songwriters. They find out whether it’s medically possible to die from a broken heart, hear from a woman who lived for 16 months without a human heart, and Xand opens up about how Long Covid is affecting his heart. Producer: Dan Hardoon
Researcher: Emily Finch
Executive Producer: Kate Holland
A Whistledown Production for BBC Radio 4

Made of Stronger Stuff: The Heart

Seriously is home to the world’s best audio documentaries and podcast recommendations, and host Vanessa Kisuule brings you two fascinating new episodes every week.

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What do Artificial Intelligence and digital technology mean for actors and their relationship with audiences? Leading acting coach Geoffrey Colman, who has spent his working life on the sets of Hollywood movies, in theatrical rehearsal spaces, and teaching in the UK's most prestigious classrooms, wants to find out.  AI, he says, may represent the most profound change to the acting business since the move from silent films to talkies. But does it, and if so how are actors dealing with it? What does that mean for the connection between actors and audiences? Geoffrey's concern is rooted in acting process: the idea that the construction of a complex inner thinking architecture resonates with audiences in an authentic almost magical way. But if performance capture and AI just creates the outer facial or physical expression, what happens to the inner joy or pain of a character’s thinking? The implications for the actor’s technique are profound. To get to the bottom of these questions Geoffrey visits some of those at the cutting edge of developing this new technology. On the storied Pinewood lot he visits Imaginarium Studios, and is shown around their 'volume', where actors' every movement is captured. In East London he talks to the head of another studio about his new AI actor - made up from different actors' body parts. And at a leading acting school he speaks to students and teachers about what this new digital era means for them. He discusses concerns about ethical questions, hears from an actor fresh from the set of a major new movie, quizzes a tech expert already using AI to create avatars of herself, and speaks to Star Wars fans about how this technology has allowed beloved characters to be rejuvenated, and even resuscitated. Producer: Giles Edwards

Counterfeit Characters

Richard King explores the past and present of the second homes debate in Wales, revisiting the story of Meibion Glyndwr – active terrorists on British soil for almost 15 years.
 
The proliferation of second homes is a problem in many parts of the UK. They contribute to pushing up house prices, often in low-income areas, effectively locking young people out of the housing market. It’s a problem with different characteristics in different places.  In Wales it is compounded by the fate of Cymraeg, the Welsh language.  It is felt by many that second homes contribute to the fragmentation of Welsh-speaking communities and pose a threat to the survival of the language.  It's nothing new. Beginning in 1979, Meibion Glyndwr – Sons of Glyndwr (Owain Glyndwr being a soldier who led a revolt against English rule in the 1400s) – responded to this threat by carrying out hundreds of arson attacks and fire-bombings. Initially targeting second homes and holiday cottages in Welsh-speaking areas, the campaign later expanded to target estate agents, English-owned businesses and the offices of police and politicians, accompanied by stencilled letters containing extravagant nativist threats. Hundreds of properties were damaged and destroyed. It lasted until 1994 and only one person was ever convicted of a related offence. The Meibion Glyndwr campaign was audacious and shocking – and utterly ineffective.  In the thirty years since the last attack Wales has gained its own parliament and with it a measure of power to decide its own fate. And as elsewhere in the UK, the issues around second homes have only become more urgent. One of the newer policies enacted by the Welsh government is a council tax premium on second homes, with local authorities able to decide how much of a levy to apply, up to a possible 300%. Writer Richard King visits Abersoch on the Llyn Peninsula, a village very much at the sharp end of the current situation and hears from some of those who lived through the Meibion Glyndwr campaign. Featuring Robat Gruffudd, Amanda Jones, Richard Wyn Jones, Alun Lenny, Louise Overfield and Eifiona Wood. With grateful thanks to Sian Howys, Meic Parry and Dylan Roberts. (The programme contains an archive recording which refers to RS Thomas as a non-conformist minister. RS Thomas was a priest in the Anglican Church in Wales.)

Home Fires

It's 25 years since London suffered three vicious nail bomb attacks - holdalls filled with 4-inch nails and hand-made explosives planted in Brixton market, Brick Lane and in the bar of the Admiral Duncan pub in Soho, intended to cause damage to those in the immediate vicinity and to the notion of a tolerant, diverse capital city.   The attacks are recorded in photographs shared at the time by the press - of London streets strewn with damaged buildings and injured people, an x-ray of a toddler with a nail embedded in his skull, the wedding photograph of two victims (one killed, the other severely injured) and the police mugshot of the perpetrator, a far right terrorist who hoped to start a 'racial war in this country'. Fragments looks again at these images - some taken by Chris Taylor who happened to be on assignment in Soho's market photographing vegetables - to consider what it means for an instant to be captured and to endure in our memories and understanding of traumatic events. Including contributions from photographer Chris Taylor; Jonathan Cash, who survived the Soho attack, Emdad Talukder, who was injured in Brick Lane and business owner Leo Epstein.  Music composed by Alan Hall, with Eleanor McDowall (chimes) and Alan Hall (trumpet) Producer: Alan Hall
A Falling Tree production for BBC Radio Four (Photo credit: ChrisTaylorPhotography.com)

Fragments - The London Nail Bombings

How many medicines can you think of created for just one person?  The likelihood is none - which is why the world hasn’t heard of milasen yet.  But its creation, and the efforts behind it, could build a pathway towards some of the greatest advances in genomic medicine, and a new initiative being trialled in Britain has a huge role to play in making this happen.   At the age of seven, Mila Makovec became the first person in the world to be treated with a medicine created just for her.  A bubbly young girl from Colorado, Mila suffered from a very rare genetic disorder called Batten disease, which leads to a painful early death in children. Mila’s mother, Julia Vitarello, resolutely sought out scientists to try to discover a way to save her daughter.  After relentless efforts, one doctor, Timothy Yu from Boston Children’s Hospital, imagined a possible treatment for Mila. The challenge was it involved making a completely unique treatment for Mila’s specific genetic mutation. It would be novel and very expensive - but it was her only option.   Julia raised the millions of dollars required through a charity she set up in her daughter’s name, and in 2018 Mila became the one patient in the world to receive the drug milasen.  Initially, it worked, and Mila’s condition stabilised and improved. However, the treatment was given after the disease had done a great deal of damage to a small child, and Mila died when she was ten years old. There are an estimated 7,000 rare diseases in the world, affecting more than 400 million people - and most are genetic. The majority have no effective treatment.  New medicines for these conditions can’t be put through clinical trials on groups of patients because they are so rare. So, currently, such novel therapeutics can only be legally given after lengthy and costly work that is uncommercial for drug firms.    Having got so achingly close to saving her daughter, Mila’s mother is now leading efforts to make these new genetic medicines available to other children with rare diseases - and Britain is where her campaign is about to take a huge step forward.  The launch of the Rare Therapies Launch Pad is bringing together efforts from Mila’s Miracle Foundation, the UK medicine’s regulator the MHRA, Genomics England and Oxford University in an world leading attempt to build a new streamlined regulatory pathway to allow one-off drugs to be designed and approved for use in individual patients with rare diseases.  Natasha Loder, Health Editor at the Economist, tells this very personal story of how one mother’s determination to try and save her daughter could lead to a revolution in personalised medicine - one that has the potential to bring hope to millions of families.  Producer: Sandra Kanthal

Mila’s Legacy

Take a trip around the supermarket and you'll see shelves of products claiming to be 'high in protein'. Scroll through your social media and you'll find beautiful, sculpted people offering recipes and ideas for packing more protein into your diet.  Science presenters Dr Julia Ravey and Dr Ella Hubber have noticed this too. They wanted to unpick the protein puzzle to find out what it does in our bodies and how much we really need. Can this macronutrient really help us lose weight, get fit and be healthier? Along the way, they speak to Professor Giles Yeo from the University of Cambridge, Bridget Benelam from the British Nutrition Foundation, Paralympian hopeful Harrison Walsh, and food historian Pen Vogler. Presenters: Dr Julia Ravey and Dr Ella Hubber
Producer: Alice Lipscombe-Southwell
Editor: Martin Smith Credits: @thefitadam/@TSCPodcast/@tadhgmoody/@meg_squats/@aussiefitness

Made of Stronger Stuff: The Heart

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