Latest Breakthroughs in Longevity Research with Aubrey de Grey

In this episode, Jacob Watson Howland interviews Aubrey de Grey about recent advancements in longevity research. Emphasizing research in mice, de Grey discusses various interventions such as rapamycin, heterochronic bone marrow transplants, telomerase gene therapy, and senescent cell removal. De Grey explains the significance of these methods and the surprising effects they have on lifespan extension, despite the complexity of aging processes. He highlights the importance of starting experiments in middle-aged mice for better relatability and details the costs and potential of further research in this field.

00:00 Introduction to Longevity Research

00:43 The Importance of Lifespan Measurement

01:20 Recent Breakthroughs in Longevity

01:53 Multi-Intervention Experiments

03:04 Challenges and Costs of Longevity Experiments

03:30 Key Interventions in Longevity

06:22 Understanding Senescent Cells