This episode provides a comprehensive dive into the acute management of non-ST-elevation myocardial infarction (NSTEMI) and non-ST-elevation acute coronary syndromes (NSTEACS), based on the detailed UpToDate article. It covers initial diagnostic evaluations, risk stratification, and the selection of revascularization strategies, from immediate invasive to noninvasive approaches. The episode emphasizes pharmacological interventions, including antiplatelet and anticoagulant therapies, with guidance on agent selection, dosing, and duration, alongside considerations for special populations and procedural scenarios like CABG. Key subtopics are occasionally wrapped up with “if you can’t remember everything, remember this” to reinforce critical points. A must-listen for residents aiming to master NSTEMI management and prevent further cardiac events.