Calvinists contend that the sin of Adam was so destructive for the entire human race that even the mind is corrupted (the noetic effects of sin). That thesis can be challenged from a biblical viewpoint for lacking solid evidence. It isn't necessary to look for an inherent defect in man's rationality due to sin. Rather, there has been an historical influence that is particularly destructive. Paul the Apostle dealt with that negative influence in describing the human race's moral degeneration from its rejection of the true God of heaven (Romans 1).