Highlights of the literature in March include include evidence from a case series that sleep deprivation and bright light therapy may rapidly improve depressive symptoms and suicidality of patients with severe bipolar depression; a systematic review which shows that modern antidepressants have improved acute but not long-term outcomes of depression; and two family studies which suggest that mania and depression do not lie on opposite ends of a spectrum, but vary independently, consistent with recent increased awareness of mixed states in severe mental illness. Finally, the BMJ published a summary of the updated guidance for the management of psychosis by the UK National Institute for Health and Care Excellence.