JACI: In Practice Editor-in-Chief, Michael Schatz, describes the March 2021 issue, the theme of which is “Biologic Therapy in Allergy Practice.” Theme topics covered include biologic therapy for asthma, atopic dermatitis, chronic spontaneous urticaria, and chronic rhinosinusitis with nasal polyps as well as cost-effectiveness considerations. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of COVID-19, Biologics, Anaphylaxis, Asthma, Dermatitis, Drug Allergy, Food Allergy, Mast Cell Disorders, and Rhinitis. Read the issue: https://bit.ly/JAIPMarch2021. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org