This review from the European Heart Journal focuses on the use of Mendelian randomization (MR) in cardiovascular epidemiology. MR leverages genetic variants to uncover causal relationships between modifiable risk factors and various cardiovascular diseases (CVDs). By drawing parallels to randomized controlled trials (RCTs), the authors explore the principles, advantages, and limitations of MR. The article also examines MR applications in predicting the efficacy and safety of drugs targeting CVD risk factors and explores the repurposing potential of existing medications.

Research paper:

Larsson SC, Butterworth AS, Burgess S. Mendelian randomization for cardiovascular diseases: principles and applications. Eur Heart J. 2023 Dec 14;44(47):4913-4924.

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