In this episode of OSCE Talk, we break down methotrexate — a high-risk but commonly prescribed DMARD used in conditions such as rheumatoid arthritis, psoriatic arthritis, and Crohn’s disease.

We explain:

• how methotrexate works

• why it is taken once weekly (and never daily)

• the role of folic acid

• key side effects, drug interactions, and monitoring

• important counselling points around infection risk, pregnancy, and safety-netting

Clear, practical explanations you can use on the ward, in clinic, and in exams.