Methylation Explained: Testing, MTHFR, Methylated Vitamins & the Gut-Brain Connection

Ever feel like low energy, mood swings, or brain fog is holding you back? It might be methylation – the body's core biochemical process for gene regulation, detox, and neurotransmitter balance. In this 12-minute episode, we break down what methylation is, how to test for deficiency (MTHFR & homocysteine), if testing even matters, why methylated vitamins (like methylfolate & methyl-B12) outperform regular forms for many, and the gut's surprising role (bacteria in yogurt don't methylate, but microbiome influences epigenetics via B vitamins & metabolites).

Key takeaways:

• Methylation basics: Adding CH3 groups to DNA/proteins – essential for healthspan

• Deficiency signs & testing: MTHFR gene variants, homocysteine levels (goal <9 µmol/L)

• Methylated vitamins: Benefits for MTHFR folks (better absorption, no masking B12 deficiency)

• Gut connection: Bacteria produce B12 (methylation cofactor); microbiome shapes DNA methylation patterns

• Protocols: Supplements, diet tweaks, when to test

If you're optimizing for longevity, mood, or detox – this is your primer.

Download the free Methylation Cheat Sheet (testing guide, supplement doses, gut tips)

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