This episode explores adenoviruses, medium-sized, non-enveloped double-stranded DNA viruses known for environmental resilience and broad tissue tropism. Drawing from Murray’s Chapter 42, it examines how structural stability supports widespread transmission.

The narrative begins with viral architecture: icosahedral symmetry with distinctive fibre projections that mediate cellular attachment. Their lack of an envelope makes them resistant to drying, detergents, and environmental stress - enabling efficient spread in community settings.

Clinically, adenoviruses are associated with:

* Pharyngitis and respiratory illness

* Conjunctivitis, including epidemic keratoconjunctivitis

* Gastroenteritis, particularly in children

* Haemorrhagic cystitis

* Severe disease in immunocompromised hosts

The episode emphasises inflammatory pathology rather than latency. Unlike herpesviruses, adenoviruses generally cause acute, self-limited infection, though they may persist in lymphoid tissue.

Conceptually, adenoviruses represent structural durability paired with mucosal targeting. Clinically, infection control - especially in institutional settings - becomes central.

Key Takeaways

* Adenoviruses are non-enveloped double-stranded DNA viruses

* Environmental stability enhances transmission

* Commonly cause respiratory and ocular infections

* Severe disease may occur in immunocompromised patients

* Infection control limits outbreaks

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drmanaankarray.substack.com/subscribe