Episode Description

This episode examines three morphologically distinctive families of enveloped negative-sense RNA viruses. Drawing from Murray’s Chapter 50, it explores how structure and tropism define clinical severity.

The first focus is rhabdoviruses, particularly rabies virus, characterised by its bullet-shaped virion. Rabies uniquely travels along peripheral nerves to the central nervous system, producing fatal encephalitis if untreated. The slow axonal transport provides a window for post-exposure prophylaxis - a rare example where timing can prevent near-certain mortality.

Next are filoviruses, including Ebola and Marburg viruses. These filamentous viruses cause severe systemic disease marked by endothelial dysfunction, immune dysregulation, and haemorrhagic manifestations. High viral replication and cytokine storm contribute to vascular collapse.

Finally, bornaviruses, though less commonly encountered, illustrate persistent infection within neural tissue.

Conceptually, this chapter demonstrates that viral morphology often reflects transmission and tropism. Clinically, early intervention, isolation, and public health containment are critical.

Key Takeaways

* Rhabdoviruses include rabies virus, which travels via peripheral nerves

* Filoviruses cause severe haemorrhagic fever

* Negative-sense RNA genomes require polymerase carriage

* Post-exposure prophylaxis can prevent rabies

* Strict infection control limits filovirus spread

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