The Bills and Patriots have faced off a total of 121 times and this Monday night it'll be the 122nd time. Buffalo won the 1st meeting of the season 24-21. Patriots quarterback Cam Newton had the ball on an option run Cam Slam play. Bills d-lineman Justin Zimmer knocked the ball lose and the Buffalo Bills held on to win a close 1. The Patriots 6-8 were eliminated from the 2021 tournament last Sunday in a lose to the Miami Dolphins 22-12. Splitting the season series with them. 21-11 was the score of that game. The Bills are already AFC East champions, for the 1st time in 25 years.