We will review the beginning of experimental and theoretical studies of moire systems and their evolution up to present. We will show how thousands of p orbitals in a moire unit cell of graphene can create single Heavy fermion at moire scale, and how the interaction between such fermions can lead to a perfect quantum simulator of an Anderson model. We will then present a catalogue of possible twistable materials and show how a huge variety of strongly interacting models can be realized in twisted homo and hetero twiste bilayers and multilayers of these materials.