In this expert highlight, Dr. Robert Wong shares essential tips for monitoring and managing patients with Primary Biliary Cholangitis (PBC). He outlines key goals after diagnosis, including evaluating liver disease severity through imaging and lab-based non-invasive testing, and assessing treatment eligibility. Dr. Wong explains the importance of monitoring alkaline phosphatase (ALP) levels—not only to guide treatment initiation but also to measure treatment response, with normalization signaling a complete response. Beyond labs, he emphasizes the need to assess patient-reported outcomes such as fatigue and pruritus, which directly impact quality of life. He also discusses the challenges of interpreting non-invasive fibrosis tools in PBC, highlighting the importance of longitudinal monitoring to track disease direction over time. Finally, Dr. Wong stresses patient engagement—using consistent follow-up, clear education, and linking lab results with symptom improvements to keep patients motivated in their care journey. This practical overview offers valuable insights for clinicians and patients aiming to optimize outcomes in PBC management.