The story follows Dek, a "runt" of the Yautja species who is considered weak by his clan’s standards. After his older brother, Kwei, is killed by their own father (the clan leader Njohrr) for refusing to execute Dek, Dek is exiled to the "death planet" Genna.

To prove his worth and regain his honor, Dek sets out to hunt the Kalisk, a legendary apex predator with near-instant regenerative abilities. Along the way, he forms an unlikely alliance with Thia (Elle Fanning), a damaged Weyland-Yutani android whose team was slaughtered by the Kalisk.

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