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mRNA Vaccine Effectiveness Against Omicron Subvariants
Vidcast: https://youtu.be/-jApZNB4yAw
Just how effective are the Pfizer and Moderna vaccines for protection against the two Omicron subvariants BA.1 and BA.2? The answer comes from a collaborative study from the epidemiologists at Cornell Medicine-Qatar following their study of 1,308,926 individuals who received the Pfizer and 894,142 who received the Moderna. Of these groups, only 27% received the Pfizer booster and 16% received the Moderna booster.
Both mRNA CoVid vaccines were only about 45% protective against a symptomatic infection by either Omicron subvariant and only for about 3 months after the 2 dose vaccination. It required a booster to maintain that protection longer-term. Protection against a severe or deadly Omicron infection was 70-80% after the 2 dose vaccination longer-term but rose to more than 90-% after a booster.
In this first set of graphs, we can see that both Pfizer and Moderna vaccines worked about the same against OmicronBA1 and OmicronBA2. The performance of the Moderna vaccine was a bit better but more variable than the Pfizer often performing better against the OmicronBA1 than OmicronBA2.
In the second set of graphs, we see that the 2 dose vaccination worked better against a severe or deadly infection than a milder infection over time, but the addition of the booster worked even better. Again, the performance of the Moderna vaccine was somewhat better but more variable than the Pfizer.
The bottom line: To maintain the best protection against either Omicron subvariant, you need the 2 shot vaccination plus the booster. Even with those, you might develop a mild infection but you’ll obtain fairly good protection against a hospitalization or death.
Keep in mind though, you don’t want any CoVid infection due to the chances of Long CoVid. Now that another wave is upon us, you’ll need to mask indoors and on transit, and you should stay out of unmasked crowds.
https://www.medrxiv.org/content/10.1101/2022.03.13.22272308v1.full.pdf
#CoVid #omicron #BA1 #BA2 #hospitalization #death
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By Howard G. Smith MD, AM
Vidcast: https://youtu.be/-jApZNB4yAw
Just how effective are the Pfizer and Moderna vaccines for protection against the two Omicron subvariants BA.1 and BA.2? The answer comes from a collaborative study from the epidemiologists at Cornell Medicine-Qatar following their study of 1,308,926 individuals who received the Pfizer and 894,142 who received the Moderna. Of these groups, only 27% received the Pfizer booster and 16% received the Moderna booster.
Both mRNA CoVid vaccines were only about 45% protective against a symptomatic infection by either Omicron subvariant and only for about 3 months after the 2 dose vaccination. It required a booster to maintain that protection longer-term. Protection against a severe or deadly Omicron infection was 70-80% after the 2 dose vaccination longer-term but rose to more than 90-% after a booster.
In this first set of graphs, we can see that both Pfizer and Moderna vaccines worked about the same against OmicronBA1 and OmicronBA2. The performance of the Moderna vaccine was a bit better but more variable than the Pfizer often performing better against the OmicronBA1 than OmicronBA2.
In the second set of graphs, we see that the 2 dose vaccination worked better against a severe or deadly infection than a milder infection over time, but the addition of the booster worked even better. Again, the performance of the Moderna vaccine was somewhat better but more variable than the Pfizer.
The bottom line: To maintain the best protection against either Omicron subvariant, you need the 2 shot vaccination plus the booster. Even with those, you might develop a mild infection but you’ll obtain fairly good protection against a hospitalization or death.
Keep in mind though, you don’t want any CoVid infection due to the chances of Long CoVid. Now that another wave is upon us, you’ll need to mask indoors and on transit, and you should stay out of unmasked crowds.
https://www.medrxiv.org/content/10.1101/2022.03.13.22272308v1.full.pdf
#CoVid #omicron #BA1 #BA2 #hospitalization #death