In this episode of Daily Value, we look inside the NAD+ wars - breaking down the science, the hype, and the controversy surrounding Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). These two molecules have been promoted as keys to longevity, but the story is far more complex. We’ll look at the biochemistry of NAD+ metabolism, compare what the research really says about NR and NMN, and dig into the regulatory drama that’s shaped their (NMN’s) availability. Most importantly, we’'ll look at a bigger-picture strategy for restoring NAD+, one that goes beyond precursors alone.

00:00 the NAD Wars

01:02 Understanding NAD+ and Its Importance

01:52 The Role of NR and NMN in NAD+ Replenishment

02:29 Biochemical Pathways of NAD+ Production

04:14 Challenges and Regulatory Issues with NMN and NR

05:44 Clinical Research and Safety Profiles

07:13 Complexities in Boosting NAD+ Levels

09:04 Multi-Targeted Strategies for NAD+ Restoration

13:25 Conclusion: Embracing Complexity in Aging

PMID: 35134387

PMID: 39026037

doi:10.1002/fft2.511