Over the last two decades, there have been several landmark fluid resuscitation trials published. These trials have provided evidence that the type of intravenous fluids we choose for resuscitation can impact important patient-centred outcomes.  This presentation will look at what we know from these trials focused on fluid resuscitation in sepsis and septic shock; specifically, an overview of the principles of fluid resuscitation, types of fluids, review the fluid resuscitation evidence and describe changes in fluid resuscitation practices over time.