Coming Off GLP-1s (Mounjaro): Maintenance, Side Effects, Cost & What to Do Next

MC of Healthy by George shares her dilemma about whether to come off GLP-1 medication after being on Mounjaro for 2.5 years and reaching her lowest weight in 40 years, while still considering a higher dose. She discusses common reasons people want to stop—side effects, satisfaction with current weight, and ongoing monthly cost—and emphasizes that long-term success still requires calorie deficit, whole foods, tracking, and regular movement. Drawing from periods off the drug for surgeries, she notes increased hunger and returning “food chatter,” though she maintained most of her loss by focusing on protein, vegetables, and mindful eating. She encourages working with a doctor to taper or adjust dosing and using tools like Lose It and Pacer to monitor calories, steps, and macros, especially with PCOS.

00:00 GLP One Crossroads

01:41 Why These Drugs Matter

03:18 Beyond The Shot

05:28 Movement In Small Bites

07:00 Coming Off Experience

07:50 Mindful Eating And Food Noise

10:11 Doctor Guided Taper Plan

10:45 Tracking Apps And Macros

11:58 Long Term Strategy And PCOS

13:48 Health Is Wealth Closing

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