A tick bite in Maine leads to an unexpected diagnosis, challenging our understanding of alpha-Gal syndrome's geographic boundaries. This episode unravels the expanding reach of this unique allergic condition, now found from coast to coast and linked to multiple tick species. We explore recent case studies that highlight the need for increased clinical suspicion, even in non-endemic areas. Learn about the diverse symptom presentation, from delayed anaphylaxis to chronic urticaria and GI distress, and the potential cardiovascular implications. Discover how alpha-Gal syndrome intersects with common medications and why it's becoming a crucial consideration in idiopathic anaphylaxis and IBS workups. Gain insights into emerging diagnostic approaches and legislative efforts to address this growing public health concern.

Resources and references available at: https://www.thermofisher.com/phadia/us/en/resources/immunocast/unmasking-alpha-gal-new-vectors-regions-concerns.html?cid=0ct_3pc_05032024_9SGOV4