NEBinspired blog

Discover how obelisks, phage satellites, jumbo phages, and Borgs are reshaping our understanding of microbial evolution and genome biology.

In this interview, PeptiFinder Biotech scientists share why mRNA Display is such a powerful platform for peptide therapeutics discovery, where they see this field going, and how enzyme engineering and workflow optimization could further expand the chemical space accessible to mRNA display.

Cell-free protein synthesis (CFPS) workflows allow for fast, scalable and cost-effective single-chain antibody fragment production. NEB scientists have outlined approaches to quickly and efficiently screen the discovery and initial characterization of novel antibody fragments with CFPS.

RNA research has translated into RNA-based clinical therapeutics. Unfortunately, post-IVT reaction components removal and purification steps are a real slog in RNA manufacturing. The constraints motivated Dr. Craig Martin's lab to rethink how IVT systems could be designed from the ground up.

Plastics are an undeniable burden in the life sciences, but scientists can switch to greener, more sustainable products, like Monarch nucleic acid purification kits. In this blog, learn how Monarch offers a more sustainable solution while maintaining high quality and affordability.

Cell-free dbDNA provides a fast, enzymatic method for producing high-quality DNA without bacterial fermentation required with plasmids. By simplifying workflows and reducing impurities, it shortens development timelines and accelerates RNA and DNA therapeutic programs from design to clinic.

Choosing the right restriction enzyme is a critical first step of in vitro transcription for mRNA vaccine and therapeutic production. This post discusses key factors that influence enzyme choice and explains how careful selection supports efficient IVT, reduces unwanted by‑products, and enables scalable, compliance‑ready mRNA manufacturing.

Annealing temperature is a critical parameter that can determine PCR specificity and yield. Some workflows benefit from a single thermocycling protocol across numerous primer sets. NEB scientists evaluated the benefits and limitations of using a universal annealing temperature to achieve robust amplification across diverse targets.

This post highlights the advantages, considerations and comparisons of postbac, postdoc and internship experiences for those developing careers in the life sciences, and shares helpful insights from our student internship coordinator and one of our postdoc fellows.

Read about a new decentralized workflow from NEB researchers that's redefining how scientists synthesize genes. By combining data-optimized design with advanced assembly techniques, this approach delivers sequence-verified constructs in as little as four days—at a fraction of the traditional cost. With faster turnaround, higher fidelity, and fewer external dependencies, this workflow enables researchers to conduct complex gene synthesis projects more efficiently and at greater scale, supporting broader access to advanced synthetic biology methods.