Vidcast: https://youtu.be/QlcoUtNbGlQ

Investigators at the Japanese company NanoCarrier Ltd. have developed technology to deliver so-called naked mRNA, that is mRNA not wrapped in a lipid container, directly into the skin without a needle. Using jet injection, the mRNA that encodes for a vaccine protein is forced into a person’s skin layers rather than into the sub-skin, the subcutaneous layer, or into the muscle layer. Once in the skin, the mRNA codes for protein that triggers an immune reaction likely stronger than that initiated by an intramuscular injection. The skin itself has a large number of immune cells capable of stimulation. In addition, the protein antigen streams quickly from skin into regional lymph node immune factories where abundant antibodies and killer T cells are generated. Successfully tested in mice, the system is headed for human trials and then into the clinic.

https://www.biorxiv.org/content/10.1101/2023.02.27.530188v1

#mRNA #vaccine #needleless #jetinjection