The sermon explores the importance of recognizing and responding to God's call, drawing from the example of Nehemiah's concern for the afflicted state of Jerusalem and his subsequent actions. It emphasizes the necessity of combining deep prayer with careful Bible study to discern God's will and encourages listeners to actively seek and fulfill their unique purpose, moving beyond basic Christian practices to embrace a proactive engagement with scripture and a willingness to address burdens and claim God's promises, ultimately demonstrating that obedience to God's word leads to a life of purpose and service.