The sermon explores the example of Nehemiah as a model for recognizing and responding to God's call to service. It emphasizes the importance of diligent study of Scripture, including historical context and practical application, and highlights the need for persistent prayer, confession, and claiming God's promises before embarking on a divinely appointed task. The message encourages listeners to identify their own unique burdens, seek guidance from others, and actively engage in serving God, recognizing that opposition is a natural consequence of pursuing His will and that He will provide the necessary resources and support for those who faithfully seek Him.