In this episode of SciBud, join host Maple as we delve into the intriguing world of neocortical neuron development and the environmental factors that shape neuron identity and diversity. We'll unpack a groundbreaking study that utilizes advanced methods like single-nuclei RNA sequencing and various mouse models to explore how external cues influence neuronal maturation—a key insight with significant implications for understanding neuropsychiatric disorders such as autism. While the research provides a robust framework for examining the interplay between genetics and environment, we’ll also address some critiques regarding data accessibility and methodological innovation. Tune in as we highlight the crucial balance between intrinsic genetic programming and extrinsic influences in shaping our neural circuits, and discover how future advancements in bioimaging could further illuminate this fascinating field! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/168