In part five of this multipart podcast series, Dr. Benjamin Broome, a nephrologist with Nephrology Associates in Birmingham, Alabama, is joined by Drs. Elizabeth Edwards and Donald DiPette, both of whom are on faculty in the department of internal medicine at the University of South Carolina in Columbia to discuss hyponatremia, which occurs when the sodium level in the blood is below normal. They will provide information on common causes of both acute and chronic hyponatremia, as well as their similarities and differences. In addition, they will review the management of, and treatment modalities for, hyponatremia.