This episode of NETRF’s NETWise podcast discusses Peptide Receptor Radionuclide Therapy (PRRT) a targeted form of radiotherapy approved in the U.S. in 2018. Listen in as NET experts like Josh Mailman, Drs. George Fisher, Thor Halfdanarson, Ed Wolin, Richard Baum, and others explain what it is, how it works, and who is most likely to benefit from PRRT. This therapy relies on a tumor’s expression of somatostatin receptors. We explain what they are and how to know if you have them.

Then, we’ll take an objective look at the success rates for this therapy. What does research, like the NETTER-1 study, tell us about outcomes for this form of treatment? To give you information about both the pros and cons of PRRT, we will also discuss the potential side effects, from mild to serious. To give you a sense of what it is like to undergo PRRT, we’ll talk with multiple patients about their experience with the procedure itself, as well as the radiation safety precautions patients should take immediately following treatment. Finally, we look to the future asking Drs. Rod Hicks and Tom Hope to explain some of the new therapeutic directions PRRT is taking.

PRRT for NETs. This handout explains how radioactive drugs are able to target NET cells with radioactivity using PRRT.

What is PRRT? A quick guide to answer your most basic questions about the pros and cons of PRRT.  What are the benefits of PRRT? What are the potential side effects of PRRT?  Who can be treated with PRRT? 

Nuclear Medicine Treatments

Gallium-68 Dotatate PET/CT Scan

Search for PRRT treatment Centers Near You

What’s Next in PRRT Treatment

VIDEO: How PRRT Works and Who Benefits – Dr. Blase Polite, University of Chicago

VIDEO: What to Expect During PRRT Treatment – Karen Ohara, Rush University Medical Center

VIDEO: How PRRT Can Improve Care for NET Patients

VIDEO: Combining PRRT with Targeted Therapy

VIDEO: Tb-161: Exploring a New Radionuclide for PRRT

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Information and Resources for the Newly Diagnosed

NETRF YouTube Channel

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