In this episode, we delve into a crucial aspect of perioperative care in neurosurgery: the selection of intravenous crystalloid solutions and their impact on acid-base balance. We will be discussing the findings from a randomized clinical trial published in Einstein (Sao Paulo, Brazil) in 2026. The study evaluated the effects of Plasma-Lyte 148 compared to 0.9% saline on acid-base and hydroelectrolyte balance in adult patients undergoing elective neurosurgical procedures. Tune in to understand the key findings of this research and how they can inform your clinical practice in managing fluid therapy for neurosurgical patients. Please note: This podcast is for informational purposes and does not constitute medical advice. The content is based on an abstract and should not be a substitute for professional medical judgment.