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Neuropsychiatry of fearlessness, bilateral amygdala dysfunction in Urbach-Wiethe disease
In this video, I discuss the general concept of how our body and mind provide 'danger' signals in response to harmful stimuli in our environment (e.g. pain) and body (e.g. acidosis).
I focus on the pathology and neuropsychology of fear-conditioning, using bilateral amygdala dysfunction (Urbach-Wiethe disease) as an example
References
Feinstein, J., Buzza, C., Hurlemann, R., Follmer, R., Dahdaleh, N., Coryell, W., Welsh, M., Tranel, D. and Wemmie, J. (2013). Fear and panic in humans with bilateral amygdala damage. Nature Neuroscience, 16(3), pp.270-272.
Hamada, T. (2002). Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Human Molecular Genetics, 11(7), pp.833-840.
Nagasako, E., Oaklander, A. and Dworkin, R. (2003). Congenital insensitivity to pain: an update. Pain, 101(3), pp.213-219.
Thornton, H., Nel, D., Thornton, D., van Honk, J., Baker, G. and Stein, D. (2008). The Neuropsychiatry and Neuropsychology Of Lipoid Proteinosis. Journal of Neuropsychiatry, 20(1), pp.86-92.
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By Damian AmendraIn this video, I discuss the general concept of how our body and mind provide 'danger' signals in response to harmful stimuli in our environment (e.g. pain) and body (e.g. acidosis).
I focus on the pathology and neuropsychology of fear-conditioning, using bilateral amygdala dysfunction (Urbach-Wiethe disease) as an example
References
Feinstein, J., Buzza, C., Hurlemann, R., Follmer, R., Dahdaleh, N., Coryell, W., Welsh, M., Tranel, D. and Wemmie, J. (2013). Fear and panic in humans with bilateral amygdala damage. Nature Neuroscience, 16(3), pp.270-272.
Hamada, T. (2002). Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Human Molecular Genetics, 11(7), pp.833-840.
Nagasako, E., Oaklander, A. and Dworkin, R. (2003). Congenital insensitivity to pain: an update. Pain, 101(3), pp.213-219.
Thornton, H., Nel, D., Thornton, D., van Honk, J., Baker, G. and Stein, D. (2008). The Neuropsychiatry and Neuropsychology Of Lipoid Proteinosis. Journal of Neuropsychiatry, 20(1), pp.86-92.