The brain is a daunting therapeutic challenge. This year's edition of Neuropsychopharmacology Reviews provides an update on treatments for brain disorders ranging from schizophrenia to neurodegeneration. Join Kerri Smith as she talks to Gwenn Smith, editor of this year's volume, about current therapies such as drugs, electrical stimulation and cognitive therapies, and the future of neurotherapeutics in an era of uncertain funding.

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