In this enlightening episode of Research Renaissance, host Deborah Westphal engages in a compelling conversation with Dr. Elisa Canepa, a neurobiologist and associate scientist from Temple University and a 2022 Toffler Scholar. Dr. Canepa shares her journey into neuroscience, driven by a fascination with the brain's complexity and its pivotal role in shaping our identity and cognitive functions. They delve into Dr. Canepa’s cutting-edge research on cerebral vascular dysfunction, particularly focusing on the potential of carbonic anhydrase inhibitors (CAIs) in treating Alzheimer's disease.

Key Discussion Points:

1. Introduction to Dr. Elisa Canepa:
   • Background and inspiration for pursuing neuroscience.
   • Current role at Temple University and involvement with the Karen Toffler Charitable Trust.
2. Research Focus:
   • Investigation into the role of carbonic anhydrase inhibitors in Alzheimer's treatment.
   • Mechanisms behind CAIs’ ability to rescue cognitive functions and ameliorate neurovascular dysfunction.
   • Recent findings published in the Alzheimer's and Dementia Journal.
3. Experimental Techniques:
   • Behavioral tasks to measure cognitive impairment and the effectiveness of treatments in animal models.
   • Advanced techniques like RNA sequencing and RNA scope to study the molecular changes in the brain.
4. Impact of High Altitude Physiology:
   • Exploration of the physiological differences in people living at high altitudes and potential insights for Alzheimer's research.
5. Future Directions and Challenges:
   • Potential clinical applications and the pathway to clinical trials for CAIs.
   • The importance of interdisciplinary collaborations and combining different expertise to advance research.
   • The role of biomarkers and advanced imaging techniques in predicting and diagnosing neurological diseases.
6. Personal and Professional Insights:
   • Dr. Canepa’s reflections on the importance of raising awareness about Alzheimer's disease.
   • The significance of combining basic science research with outreach and advocacy efforts.
   • The global nature of neurodegenerative research and collaborations across countries.
7. Emerging Research Areas:
   • Investigations into tauopathies and their impact on vascular health.
   • The intersection of cardiovascular health and Alzheimer's disease, particularly in the context of Western diets and lifestyle factors.

Join us in advancing our understanding of the brain and addressing its ailments. Until then, onward and upward!

To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org.

Technical Podcast Support by Jon Keur at Wayfare Recording Co.