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New Approach To Stopping Diabetic Blood Vessel Damage
Vidcast: https://www.instagram.com/p/C3Gd8J9LAmk/
A novel approach to preventing diabetic eye and kidney disease employs an enzyme inhibitor that prevents damage to the linings of the tiniest blood vessels.
Research nephrologists at the UK’s University of Bristol have developed a heparanase inhibitor drug, OVZ/HS-1638, that prevents enzymatic damage to blood vessel linings, the so-called endothelial glycocalyx. Using a mouse model, the investigators show that this agent can effectively prevent heparan sulfate damage in the glycocalyx and the development of retinal and renal vessel damage.
Over 8% of the world’s population suffers from diabetes and the most devastating aspect of this disease is damage to small vessels in not only the eyes and kidneys but also in the cardiovascular system. Such damage causes blindness, kidney failure, heart disease, stroke, and peripheral vascular disease. This enzyme inhibitor and others like it that protect the delicate blood vessel linings could be a powerful weapon in the fight to control the ravages of diabetes.
https://cardiab.biomedcentral.com/articles/10.1186/s12933-024-02133-1
#diabetes #eye #kidney #endothelial #heparanase #glycocalyx #ubristol
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By Howard G. Smith MD, AMVidcast: https://www.instagram.com/p/C3Gd8J9LAmk/
A novel approach to preventing diabetic eye and kidney disease employs an enzyme inhibitor that prevents damage to the linings of the tiniest blood vessels.
Research nephrologists at the UK’s University of Bristol have developed a heparanase inhibitor drug, OVZ/HS-1638, that prevents enzymatic damage to blood vessel linings, the so-called endothelial glycocalyx. Using a mouse model, the investigators show that this agent can effectively prevent heparan sulfate damage in the glycocalyx and the development of retinal and renal vessel damage.
Over 8% of the world’s population suffers from diabetes and the most devastating aspect of this disease is damage to small vessels in not only the eyes and kidneys but also in the cardiovascular system. Such damage causes blindness, kidney failure, heart disease, stroke, and peripheral vascular disease. This enzyme inhibitor and others like it that protect the delicate blood vessel linings could be a powerful weapon in the fight to control the ravages of diabetes.
https://cardiab.biomedcentral.com/articles/10.1186/s12933-024-02133-1
#diabetes #eye #kidney #endothelial #heparanase #glycocalyx #ubristol