Associate Professor Yassir Mahgoub and his team at Penn State University have uncovered an important link between melancholia – a severe form of depression that often doesn’t respond to treatment – and catatonia – a condition characterized by abnormal movements and associated with schizophrenia. The researchers analyzed case studies involving six patients who had been hospitalized for severe depression. All six patients experienced significant relief from their depressive symptoms by taking lorazepam – a drug typically used to treat catatonia. This discovery reveals a potential new avenue for treating severe, treatment-resistant depression.