Jesus sends believers into a hostile world like sheep among wolves, but He provides a strategy for navigating opposition. Christians must learn to hear God's voice through Scripture, prayer, and godly counsel to understand their divine calling. The key is balancing shrewdness and innocence—being wise and strategic while maintaining purity and integrity. Shrewdness without innocence becomes cunning, while innocence without shrewdness becomes naivety. This balance helps believers identify genuine threats while keeping their hearts pure. The ultimate goal isn't just survival but transformation, as the gospel has power to turn wolves into sheep through faithful Christian witness.