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Head injury victims taking the blood pressure drug prazosin, branded as Minipress, experienced half as many headaches as those on an inactive placebo.  Washington state Veterans Administration healthcare researchers performed a randomized pilot study of the drug on 32 military veterans and active duty personnel.  An additional 16 received a placebo medication.  

The data revealed a 44% reduction in headache frequency for those taking prazosin compared with controls.  The percentage of participants experiencing a 50% reduction in their headaches was 70% for those taking the drug vs 29% for those on the placebo.  Of most import, the prazosin significantly reduced the impact of headaches on the participants’ everyday lives.

This preliminary study will be followed by larger, double-blinded randomized trials, but the initial results are encouraging indeed.

https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14529

#headache #concussion #prazosin