Researchers partially funded by the NIEHS Superfund Research Program (SRP) developed a model to estimate individual exposure to four per- and polyfluoroalkyl substances (PFAS) commonly found in drinking water. The model integrates published data from multiple studies on PFAS levels in human blood along with measured PFAS concentrations in drinking water. Tools for estimating PFAS exposure from contaminated drinking water can inform public health risk assessments and advisories.