For Ebola. New vaccines for Bundibugyo ebolavirus

ChAdOx1 Bundibugyo vaccine (Oxford / Serum Institute)

Uses the chimpanzee adenovirus (ChAdOx1) platform

Similar technology was used in the Oxford AZ COVID-19 vaccine

Potentially be ready for early efficacy assessment in 2–3 months

How the ChAdOx system works

Genes for the antigen are inserted into a viral vector

Injection(im)

Biodistribution

Cell entry

Delivers DNA instructions into the cell

Antigen production

Cell manufactures the viral protein:

Both cause human cells to manufacture a viral antigen

COVID vaccine → spike protein

Ebola vaccine → Ebola glycoprotein

For the SARS-CoV-2, spike protein, immunologically important antigen, is believed to be associated with cells surfaces rather than freely circulating.